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This reservoir of antibiotics is likely to be used inappropriately-the Web sites promote self-diagnosis and self-medication, and antibiotics are likely to be used in inappropriate dosages. This phenomenon has not been the focus of initiatives to control antibiotic resistance. Finally, in order to determine whether these sites actually provide a product that they intended to sell over the counter, we submitted an online order to 1 vendor for 6 tablets of azithromycin, 500 mg each. Fourth, we categorized whether a person could buy antibiotics, especially broad-spectrum antibiotics, in quantities greater than what would be considered adequate 1 course of treatment for acute respiratory tract infection. Reducing inappropriate use of antibiotics is key to many antibiotic resistance initiatives. The links to these advertised sites were also investigated. Some prescription medication is sold without a valid prescription, which is a violation of the Federal Food, Drug, and Cosmetic Act. Our study suggests that the opposite might be the case. Second, there was a considerable repetition in the Web sites, which made an accurate determination of unique vendors from the 184 different sites difficult, an effort that may have let to some error. As websites appear and disappear at a relative frequency, searches and classifications were performed during the first week of September 2008. Increased regulation of sites outside of controlled substances to include antibiotics seems guaranteed and necessary. Our purchase arrived from Mexico with no information on instructions for use of the medication. As some vendors have multiple URLs to reach their company, we checked the mailing address, title and phone number to avoid double counting. Thus, vendors targeting foreign-language speakers in the United States would have been missed. Since the websites suggested a range of days for the expected treatment receipt, we used the median to represent the expected delivery time.