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Patients are increasingly using the Internet not only to access health information but also to obtain medication. As part of this study, we bought over-the-counter antibiotics over the counter. In conclusion, antibiotics are freely available for purchase over the Internet without a prescription, and the general structure of transactions encourages self-medication and poor quality care. This practice also occurs in the United States even though the United States regulates the acquisition of antibiotics, which will be limited by prescription only. Some Internet vendors also attempt to skirt US regulations by operating in countries outside the United States but marketing to US consumers. This activity suggests that some vendors are aware of the questionable legitimacy of their business. The links to these advertised sites were also investigated. Third, we could not to determine how often pharmaceuticals purchased over the Internet were not genuine, inactive, out of date, or adulterated. We considered more than 6 pills to be excessive and could lead to future self-medication with the unused pills. Although the vast majority of websites were in English, some were in other languages. Second, we examined whether the vendor would ship prescription antibiotics to a buyer in the United States, as well as several other countries (Canada, United Kingdom) where antibiotics are available only by prescription. Reducing inappropriate use of antibiotics is key to many antibiotic resistance initiatives. European countries struggled with the problem of self-medication with antibiotics and found that the belief in the appropriateness of self-medication with antibiotics for bronchitis and the perceived availability of antibiotics without a prescription was associated with an increased likelihood of self-medication. Our study is the first to document this phenomenon, and we describe the mechanism for purchasing antibiotics online; future studies will need to document the scope of antibiotics purchased through this mechanism to better understand its direct implications for antibiotic resistance. No prescription was required, and no online consultation was necessary.