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Since the websites suggested a range of days for the expected treatment receipt, we used the median to represent the expected delivery time. In addition, the ability of Internet-based companies to exist without an identifiable physical location or property makes the location and writing of FDA instructions extremely difficult. The extent to which antibiotics are available for over-the-counter purchases over the Internet is unknown. There are several limitations to this study. That these companies can be located in countries outside US jurisdictions complicates enforcement of US laws. We therefore wanted to find out if the amount of time between online evaluation and getting treatment was significantly longer. Antibiotic resistance is a common problem, however, and has been described with numerous infectious agents and in varying contexts. For this second group, no prescription from a doctor or clinical physician was necessary before gaining access to the site. The frequency of relevant Web sites declined substantially after the first 300. Patients are increasingly using the Internet not only to access health information but also to obtain medication. First, this study provides a sample of websites and providers, and thus may not be indicative of all suppliers selling over-the-counter antibiotics. Our purchase arrived from Mexico with no information on instructions for use of the medication. Finally, in order to determine whether these sites actually provide a product that they intended to sell over the counter, we submitted an online order to 1 vendor for 6 tablets of azithromycin, 500 mg each. Our final list of URLs included 184 links to single vendors of antibiotics. All these obstacles cause the illegal acquisition of antibiotics by patients. Thus, vendors targeting foreign-language speakers in the United States would have been missed.