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Some prescription medication is sold without a valid prescription, which is a violation of the Federal Food, Drug, and Cosmetic Act. The extent to which antibiotics are available for over-the-counter purchases over the Internet is unknown. Because of its effect on morbidity and mortality, antibiotic resistance is considered a threat to US health and national security by the Institute of Medicine and the Infectious Diseases Society of America. Previous research suggests that a patient's past experience of care seeking and treatment use influences future expectations for treatment of respiratory tract infections. Unfortunately, this strategy of focusing on prescribing practices does not address the behavior of self-medication with antibiotics. Self-administration of antibiotics occurs in all countries, but it is particularly problematic where the use of antimicrobials without a prescription is encouraged by the lack of laws restricting antibiotic sales or a failure to enforce the laws. Fifth, we estimated the expected delivery time to take antibiotics. After completing the online medical history, the customer would be given a prescription that would allow the purchase to be completed. Third, we could not to determine how often pharmaceuticals purchased over the Internet were not genuine, inactive, out of date, or adulterated. First, although all of the included providers would sell antibiotics without a prescription, we assessed whether the supplier would sell antibiotics without any form of prescription or whether a prescription created for the purchase based on the completion of an online medical history was required. We compared identifying telephone numbers, street addresses, and site headers for each site as a way to sort out duplication. Since the websites suggested a range of days for the expected treatment receipt, we used the median to represent the expected delivery time. The first 300 search results of on both sites were examined to identify vendors for antibiotics that did not require a prescription. In the case of online histories to justify a prescription, we assumed that individuals are primarily purchasing antibiotics for an acute problem. Antibiotic resistance is a common problem, however, and has been described with numerous infectious agents and in varying contexts.