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Some prescription medication is sold without a valid prescription, which is a violation of the Federal Food, Drug, and Cosmetic Act. For this second group, no prescription from a doctor or clinical physician was necessary before gaining access to the site. Antibiotics serve a useful therapeutic purpose in treating and controlling the effects of infectious agents. The purpose of this study was to examine antibiotics available to patients without a prescription, a phenomenon on the Internet. After completing the online medical history, the customer would be given a prescription that would allow the purchase to be completed. In our analysis of evidence of the concept of buying 6 tablets of azithromycin, 500 mg each. This decrease was interpreted as evidence that the full use of antibiotics was also reduced. Reducing inappropriate use of antibiotics is key to many antibiotic resistance initiatives. Specifically, we classified a single course of azithromycin as 6 pills, 250 mg each. Although more than half of the identified sites provided online consultation for prescribing, the lack of interaction between the patient and the doctor did not lead to any opportunity for patient education. Second, there was a considerable repetition in the Web sites, which made an accurate determination of unique vendors from the 184 different sites difficult, an effort that may have let to some error. Unfortunately, this strategy of focusing on prescribing practices does not address the behavior of self-medication with antibiotics. Our final list of URLs included 184 links to single vendors of antibiotics. We compared identifying telephone numbers, street addresses, and site headers for each site as a way to sort out duplication. Self-administration of antibiotics occurs in all countries, but it is particularly problematic where the use of antimicrobials without a prescription is encouraged by the lack of laws restricting antibiotic sales or a failure to enforce the laws. Our study is the first to document this phenomenon, and we describe the mechanism for purchasing antibiotics online; future studies will need to document the scope of antibiotics purchased through this mechanism to better understand its direct implications for antibiotic resistance.