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The first 300 search results of on both sites were examined to identify vendors for antibiotics that did not require a prescription. In some cases the URL did not take the reader to an actual medication vendor; rather, the Web site contained multiple advertisements and links to other sites for purchasing antibiotics. Self-administration of antibiotics occurs in all countries, but it is particularly problematic where the use of antimicrobials without a prescription is encouraged by the lack of laws restricting antibiotic sales or a failure to enforce the laws. Because of its effect on morbidity and mortality, antibiotic resistance is considered a threat to US health and national security by the Institute of Medicine and the Infectious Diseases Society of America. We considered more than 6 pills to be excessive and could lead to future self-medication with the unused pills. In our analysis of evidence of the concept of buying 6 tablets of azithromycin, 500 mg each. Thus, as soon as patients receive over-the-counter antibiotics and self-treating self-limiting illnesses with drugs, such as upper-respiratory tract infections without complications, they are likely to suggest that the antibiotic was effective, and self-medicate in the future. The vendors identified in this study do not appear to be fearful of prosecution. As a result, most community assessments of antibiotic reservoirs are based on assessments by prescribing clinician behavior. Antibiotics serve a useful therapeutic purpose in treating and controlling the effects of infectious agents. In addition, the available quantities and the interval between prescribing and receiving treatment suggest that these transactions will likely be used by people storing drugs for future self-diagnosis and treatment, or for sale. As websites appear and disappear at a relative frequency, searches and classifications were performed during the first week of September 2008. Our study suggests that the opposite might be the case. Finally, and potentially the biggest limitation on the importance of this study, is that we were unable to describe how this Internet-based purchasing strategy was used to purchase people with antibiotics in the United States. Previous research suggests that a patient's past experience of care seeking and treatment use influences future expectations for treatment of respiratory tract infections. The purpose of this study was to examine antibiotics available to patients without a prescription, a phenomenon on the Internet.