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European countries struggled with the problem of self-medication with antibiotics and found that the belief in the appropriateness of self-medication with antibiotics for bronchitis and the perceived availability of antibiotics without a prescription was associated with an increased likelihood of self-medication. Because of its effect on morbidity and mortality, antibiotic resistance is considered a threat to US health and national security by the Institute of Medicine and the Infectious Diseases Society of America. Thus, vendors targeting foreign-language speakers in the United States would have been missed. To examine the types of Web sites and vendors dispensing antibiotics on the Internet, we conducted a search using 2 major search engines (Google and Yahoo) and the key words "purchase antibiotics without prescription" and "online (English only). Unfortunately, other disturbing evidence suggests that this problem may not be easily fixed through education, a troubling issue in controlling antibiotic use. Fifth, we estimated the expected delivery time to take antibiotics. Recent evidence in ethnic communities in the United States indicates a high level of self-medication with antibiotics either obtained without a prescription in a foreign country and imported into the United States or acquired in the United States without a prescription at stores in ethnic communities. The frequency of relevant Web sites declined substantially after the first 300. In conclusion, antibiotics are freely available for purchase over the Internet without a prescription, and the general structure of transactions encourages self-medication and poor quality care. Moreover, pharmaceutical companies may need to monitor who is selling their products and through what mechanisms. Antibiotic resistance is a common problem, however, and has been described with numerous infectious agents and in varying contexts. Increased regulation of sites outside of controlled substances to include antibiotics seems guaranteed and necessary. Although providing over-the-counter drugs is illegal in the United States, failure to enforce US laws likely encourages these companies to sell their products to patients. This study was not meant to be an exhaustive census of these sites, primarily because with the questionable legality of some of these practices, these sites rapidly come and go. The purpose of this study was to examine antibiotics available to patients without a prescription, a phenomenon on the Internet. As websites appear and disappear at a relative frequency, searches and classifications were performed during the first week of September 2008.