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In some cases the URL did not take the reader to an actual medication vendor; rather, the Web site contained multiple advertisements and links to other sites for purchasing antibiotics. Because of its effect on morbidity and mortality, antibiotic resistance is considered a threat to US health and national security by the Institute of Medicine and the Infectious Diseases Society of America. Increased regulation of sites outside of controlled substances to include antibiotics seems guaranteed and necessary. After completing the online medical history, the customer would be given a prescription that would allow the purchase to be completed. Our study suggests that the opposite might be the case. Some Internet vendors also attempt to skirt US regulations by operating in countries outside the United States but marketing to US consumers. The extended delay between diagnosis and treatment receipt has consequences for resolving self-limiting conditions and storing unused treatment. We therefore wanted to find out if the amount of time between online evaluation and getting treatment was significantly longer. Finally, in order to determine whether these sites actually provide a product that they intended to sell over the counter, we submitted an online order to 1 vendor for 6 tablets of azithromycin, 500 mg each. Fifth, we estimated the expected delivery time to take antibiotics. Moreover, pharmaceutical companies may need to monitor who is selling their products and through what mechanisms. We assessed whether individuals could purchase penicillins, macrolides, fluoroquinolones, and cephalosporins, because the availability of multiple classes of antibiotics would affect additional selective pressure in the community. Thus, as soon as patients receive over-the-counter antibiotics and self-treating self-limiting illnesses with drugs, such as upper-respiratory tract infections without complications, they are likely to suggest that the antibiotic was effective, and self-medicate in the future. Second, we examined whether the vendor would ship prescription antibiotics to a buyer in the United States, as well as several other countries (Canada, United Kingdom) where antibiotics are available only by prescription. The first 300 search results of on both sites were examined to identify vendors for antibiotics that did not require a prescription. Unfortunately, this strategy of focusing on prescribing practices does not address the behavior of self-medication with antibiotics.