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Thus, as soon as patients receive over-the-counter antibiotics and self-treating self-limiting illnesses with drugs, such as upper-respiratory tract infections without complications, they are likely to suggest that the antibiotic was effective, and self-medicate in the future. Our purchase arrived from Mexico with no information on instructions for use of the medication. Second, there was a considerable repetition in the Web sites, which made an accurate determination of unique vendors from the 184 different sites difficult, an effort that may have let to some error. The purpose of this study was to examine antibiotics available to patients without a prescription, a phenomenon on the Internet. Unfortunately, this strategy of focusing on prescribing practices does not address the behavior of self-medication with antibiotics. The vendors identified in this study do not appear to be fearful of prosecution. The links to these advertised sites were also investigated. Self-administration of antibiotics occurs in all countries, but it is particularly problematic where the use of antimicrobials without a prescription is encouraged by the lack of laws restricting antibiotic sales or a failure to enforce the laws. Some Internet vendors also attempt to skirt US regulations by operating in countries outside the United States but marketing to US consumers. The frequency of relevant Web sites declined substantially after the first 300. In usual face-to-face health care visits for respiratory tract infections during which antibiotics are prescribed, more than 90% of prescriptions are filled on the day of the office visit. Our final list of URLs included 184 links to single vendors of antibiotics. Although the vast majority of websites were in English, some were in other languages. Further education aimed at patients and the community, as well as increased regulation and application of existing guidelines, can help control this potentially vast reservoir of antibiotics. As part of this study, we bought over-the-counter antibiotics over the counter. Antibiotics serve a useful therapeutic purpose in treating and controlling the effects of infectious agents.