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Some prescription medication is sold without a valid prescription, which is a violation of the Federal Food, Drug, and Cosmetic Act. Self-administration of antibiotics occurs in all countries, but it is particularly problematic where the use of antimicrobials without a prescription is encouraged by the lack of laws restricting antibiotic sales or a failure to enforce the laws. Third, we could not to determine how often pharmaceuticals purchased over the Internet were not genuine, inactive, out of date, or adulterated. Although the vast majority of websites were in English, some were in other languages. The extent to which antibiotics are available for over-the-counter purchases over the Internet is unknown. The extended delay between diagnosis and treatment receipt has consequences for resolving self-limiting conditions and storing unused treatment. In our analysis of evidence of the concept of buying 6 tablets of azithromycin, 500 mg each. That these companies can be located in countries outside US jurisdictions complicates enforcement of US laws. In addition, the ability of Internet-based companies to exist without an identifiable physical location or property makes the location and writing of FDA instructions extremely difficult. Third, we categorized the classes of antibiotics available for purchase. This activity suggests that some vendors are aware of the questionable legitimacy of their business. This reservoir of antibiotics is likely to be used inappropriately-the Web sites promote self-diagnosis and self-medication, and antibiotics are likely to be used in inappropriate dosages. The vendors identified in this study do not appear to be fearful of prosecution. This decrease was interpreted as evidence that the full use of antibiotics was also reduced. We compared identifying telephone numbers, street addresses, and site headers for each site as a way to sort out duplication.