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Our study suggests that the opposite might be the case. As websites appear and disappear at a relative frequency, searches and classifications were performed during the first week of September 2008. We classified Web sites of vendors according to several variables. As a result, most community assessments of antibiotic reservoirs are based on assessments by prescribing clinician behavior. In addition, the ability of Internet-based companies to exist without an identifiable physical location or property makes the location and writing of FDA instructions extremely difficult. Reducing inappropriate use of antibiotics is key to many antibiotic resistance initiatives. In some cases the URL did not take the reader to an actual medication vendor; rather, the Web site contained multiple advertisements and links to other sites for purchasing antibiotics. Other providers are trying to upset this law by providing online diagnoses and prescriptions based on medical records without a physical examination and without a long relationship between the patient and the doctor, a practice that is not considered an adequate standard of care. Most initiatives, however, focus almost exclusively on controlling prescribing by health care clinicians and do not focus on patient self-medication. Several studies suggest that antibiotic prescribing for viral illnesses, respiratory tract infections being one example, has declined in the last decade. Finally, and potentially the biggest limitation on the importance of this study, is that we were unable to describe how this Internet-based purchasing strategy was used to purchase people with antibiotics in the United States. We compared identifying telephone numbers, street addresses, and site headers for each site as a way to sort out duplication. Our purchase arrived from Mexico with no information on instructions for use of the medication. The extent to which antibiotics are available for over-the-counter purchases over the Internet is unknown. Antibiotic resistance is a common problem, however, and has been described with numerous infectious agents and in varying contexts. As some vendors have multiple URLs to reach their company, we checked the mailing address, title and phone number to avoid double counting.