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Clinicians evaluating the patient's use of self-medication when taking a medical history may function as an important opportunity to tell patients about not only antibiotic resistance, but also potential interactions between antibiotics and other prescription drugs. The purpose of this study was to examine antibiotics available to patients without a prescription, a phenomenon on the Internet. Third, we categorized the classes of antibiotics available for purchase. As some vendors have multiple URLs to reach their company, we checked the mailing address, title and phone number to avoid double counting. Moreover, pharmaceutical companies may need to monitor who is selling their products and through what mechanisms. As part of this study, we bought over-the-counter antibiotics over the counter. The links to these advertised sites were also investigated. First, although all of the included providers would sell antibiotics without a prescription, we assessed whether the supplier would sell antibiotics without any form of prescription or whether a prescription created for the purchase based on the completion of an online medical history was required. The extent to which antibiotics are available for over-the-counter purchases over the Internet is unknown. Self-administration of antibiotics occurs in all countries, but it is particularly problematic where the use of antimicrobials without a prescription is encouraged by the lack of laws restricting antibiotic sales or a failure to enforce the laws. This study was not meant to be an exhaustive census of these sites, primarily because with the questionable legality of some of these practices, these sites rapidly come and go. Third, we could not to determine how often pharmaceuticals purchased over the Internet were not genuine, inactive, out of date, or adulterated. For this second group, no prescription from a doctor or clinical physician was necessary before gaining access to the site. Thus, vendors targeting foreign-language speakers in the United States would have been missed. Unfortunately, other disturbing evidence suggests that this problem may not be easily fixed through education, a troubling issue in controlling antibiotic use.