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The findings described in this study suggest that there is a potentially large pool of antibiotics in the United States that is not affected by initiatives to change physician-prescribing practices and may be contributing to antibiotic resistance. The extent to which antibiotics are available for over-the-counter purchases over the Internet is unknown. Second, there was a considerable repetition in the Web sites, which made an accurate determination of unique vendors from the 184 different sites difficult, an effort that may have let to some error. Third, we categorized the classes of antibiotics available for purchase. In usual face-to-face health care visits for respiratory tract infections during which antibiotics are prescribed, more than 90% of prescriptions are filled on the day of the office visit. Fourth, we have limited our count to English language websites. Unfortunately, other disturbing evidence suggests that this problem may not be easily fixed through education, a troubling issue in controlling antibiotic use. As some vendors have multiple URLs to reach their company, we checked the mailing address, title and phone number to avoid double counting. Since the websites suggested a range of days for the expected treatment receipt, we used the median to represent the expected delivery time. First, although all of the included providers would sell antibiotics without a prescription, we assessed whether the supplier would sell antibiotics without any form of prescription or whether a prescription created for the purchase based on the completion of an online medical history was required. In addition, the available quantities and the interval between prescribing and receiving treatment suggest that these transactions will likely be used by people storing drugs for future self-diagnosis and treatment, or for sale. Thus, as soon as patients receive over-the-counter antibiotics and self-treating self-limiting illnesses with drugs, such as upper-respiratory tract infections without complications, they are likely to suggest that the antibiotic was effective, and self-medicate in the future. As a result, most community assessments of antibiotic reservoirs are based on assessments by prescribing clinician behavior. If those who are self-medicating are taught that they put their own health at risk, they may be less likely to use these online pharmacies. Fifth, we estimated the expected delivery time to take antibiotics. The purpose of this study was to examine antibiotics available to patients without a prescription, a phenomenon on the Internet.