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The purpose of this study was to examine antibiotics available to patients without a prescription, a phenomenon on the Internet. Antibiotics serve a useful therapeutic purpose in treating and controlling the effects of infectious agents. In usual face-to-face health care visits for respiratory tract infections during which antibiotics are prescribed, more than 90% of prescriptions are filled on the day of the office visit. Several studies suggest that antibiotic prescribing for viral illnesses, respiratory tract infections being one example, has declined in the last decade. In addition, the ability of Internet-based companies to exist without an identifiable physical location or property makes the location and writing of FDA instructions extremely difficult. After completing the online medical history, the customer would be given a prescription that would allow the purchase to be completed. Patients are increasingly using the Internet not only to access health information but also to obtain medication. Increased regulation of sites outside of controlled substances to include antibiotics seems guaranteed and necessary. Thus, vendors targeting foreign-language speakers in the United States would have been missed. As part of this study, we bought over-the-counter antibiotics over the counter. The links to these advertised sites were also investigated. Finally, in order to determine whether these sites actually provide a product that they intended to sell over the counter, we submitted an online order to 1 vendor for 6 tablets of azithromycin, 500 mg each. Our study suggests that the opposite might be the case. First, this study provides a sample of websites and providers, and thus may not be indicative of all suppliers selling over-the-counter antibiotics. Our study is the first to document this phenomenon, and we describe the mechanism for purchasing antibiotics online; future studies will need to document the scope of antibiotics purchased through this mechanism to better understand its direct implications for antibiotic resistance.