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The medical community and the public health and regulating agencies, as well as pharmaceutical companies, need to expand efforts to control antibiotic resistance beyond initiatives centered on prescribing behavior to include self-medication and sources of antibiotics obtained without prescription. The links to these advertised sites were also investigated. For this second group, no prescription from a doctor or clinical physician was necessary before gaining access to the site. The vendors identified in this study do not appear to be fearful of prosecution. Second, there was a considerable repetition in the Web sites, which made an accurate determination of unique vendors from the 184 different sites difficult, an effort that may have let to some error. Other providers are trying to upset this law by providing online diagnoses and prescriptions based on medical records without a physical examination and without a long relationship between the patient and the doctor, a practice that is not considered an adequate standard of care. Patients are increasingly using the Internet not only to access health information but also to obtain medication. The purpose of this study was to examine antibiotics available to patients without a prescription, a phenomenon on the Internet. Although providing over-the-counter drugs is illegal in the United States, failure to enforce US laws likely encourages these companies to sell their products to patients. European countries struggled with the problem of self-medication with antibiotics and found that the belief in the appropriateness of self-medication with antibiotics for bronchitis and the perceived availability of antibiotics without a prescription was associated with an increased likelihood of self-medication. The first 300 search results of on both sites were examined to identify vendors for antibiotics that did not require a prescription. After completing the online medical history, the customer would be given a prescription that would allow the purchase to be completed. We compared identifying telephone numbers, street addresses, and site headers for each site as a way to sort out duplication. Finally, and potentially the biggest limitation on the importance of this study, is that we were unable to describe how this Internet-based purchasing strategy was used to purchase people with antibiotics in the United States. Our purchase arrived from Mexico with no information on instructions for use of the medication. Unfortunately, this strategy of focusing on prescribing practices does not address the behavior of self-medication with antibiotics.