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Reducing inappropriate use of antibiotics is key to many antibiotic resistance initiatives. This activity suggests that some vendors are aware of the questionable legitimacy of their business. Finally, in order to determine whether these sites actually provide a product that they intended to sell over the counter, we submitted an online order to 1 vendor for 6 tablets of azithromycin, 500 mg each. Thus, vendors targeting foreign-language speakers in the United States would have been missed. European countries struggled with the problem of self-medication with antibiotics and found that the belief in the appropriateness of self-medication with antibiotics for bronchitis and the perceived availability of antibiotics without a prescription was associated with an increased likelihood of self-medication. As websites appear and disappear at a relative frequency, searches and classifications were performed during the first week of September 2008. As some vendors have multiple URLs to reach their company, we checked the mailing address, title and phone number to avoid double counting. Other providers are trying to upset this law by providing online diagnoses and prescriptions based on medical records without a physical examination and without a long relationship between the patient and the doctor, a practice that is not considered an adequate standard of care. Second, there was a considerable repetition in the Web sites, which made an accurate determination of unique vendors from the 184 different sites difficult, an effort that may have let to some error. Most initiatives, however, focus almost exclusively on controlling prescribing by health care clinicians and do not focus on patient self-medication. Although the vast majority of websites were in English, some were in other languages. There are several limitations to this study. No prescription was required, and no online consultation was necessary. We compared identifying telephone numbers, street addresses, and site headers for each site as a way to sort out duplication. The frequency of relevant Web sites declined substantially after the first 300. All these obstacles cause the illegal acquisition of antibiotics by patients.