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Further education aimed at patients and the community, as well as increased regulation and application of existing guidelines, can help control this potentially vast reservoir of antibiotics. Second, we examined whether the vendor would ship prescription antibiotics to a buyer in the United States, as well as several other countries (Canada, United Kingdom) where antibiotics are available only by prescription. To examine the types of Web sites and vendors dispensing antibiotics on the Internet, we conducted a search using 2 major search engines (Google and Yahoo) and the key words "purchase antibiotics without prescription" and "online (English only). This activity suggests that some vendors are aware of the questionable legitimacy of their business. That these companies can be located in countries outside US jurisdictions complicates enforcement of US laws. No prescription was required, and no online consultation was necessary. We considered more than 6 pills to be excessive and could lead to future self-medication with the unused pills. As part of this study, we bought over-the-counter antibiotics over the counter. For example, we found that servers at Dartmouth College, East Carolina University, University of Pittsburgh, Carnegie Mellon University, and California State University in San Francisco were all used, most likely without their knowledge, to be reassigned to online pharmacies. In conclusion, antibiotics are freely available for purchase over the Internet without a prescription, and the general structure of transactions encourages self-medication and poor quality care. Some prescription medication is sold without a valid prescription, which is a violation of the Federal Food, Drug, and Cosmetic Act. Some Internet vendors also attempt to skirt US regulations by operating in countries outside the United States but marketing to US consumers. As a result, most community assessments of antibiotic reservoirs are based on assessments by prescribing clinician behavior. Because of its effect on morbidity and mortality, antibiotic resistance is considered a threat to US health and national security by the Institute of Medicine and the Infectious Diseases Society of America. The first 300 search results of on both sites were examined to identify vendors for antibiotics that did not require a prescription. The extended delay between diagnosis and treatment receipt has consequences for resolving self-limiting conditions and storing unused treatment.