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Clinicians evaluating the patient's use of self-medication when taking a medical history may function as an important opportunity to tell patients about not only antibiotic resistance, but also potential interactions between antibiotics and other prescription drugs. For this second group, no prescription from a doctor or clinical physician was necessary before gaining access to the site. Increased regulation of sites outside of controlled substances to include antibiotics seems guaranteed and necessary. Other providers are trying to upset this law by providing online diagnoses and prescriptions based on medical records without a physical examination and without a long relationship between the patient and the doctor, a practice that is not considered an adequate standard of care. If patients who are now denied antibiotics through their physician can access over-the-counter medications, the overall level of antibiotic use in the general population can actually increase and thus have a significant effect on rates of resistance to microbial degradation. Fourth, we have limited our count to English language websites. The frequency of relevant Web sites declined substantially after the first 300. Our purchase arrived from Mexico with no information on instructions for use of the medication. This practice also occurs in the United States even though the United States regulates the acquisition of antibiotics, which will be limited by prescription only. In addition, the ability of Internet-based companies to exist without an identifiable physical location or property makes the location and writing of FDA instructions extremely difficult. No prescription was required, and no online consultation was necessary. Our final list of URLs included 184 links to single vendors of antibiotics. For example, we found that servers at Dartmouth College, East Carolina University, University of Pittsburgh, Carnegie Mellon University, and California State University in San Francisco were all used, most likely without their knowledge, to be reassigned to online pharmacies. The extent to which antibiotics are available for over-the-counter purchases over the Internet is unknown. Fifth, we estimated the expected delivery time to take antibiotics.