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The frequency of relevant Web sites declined substantially after the first 300. We classified Web sites of vendors according to several variables. As websites appear and disappear at a relative frequency, searches and classifications were performed during the first week of September 2008. Several studies suggest that antibiotic prescribing for viral illnesses, respiratory tract infections being one example, has declined in the last decade. Further education aimed at patients and the community, as well as increased regulation and application of existing guidelines, can help control this potentially vast reservoir of antibiotics. First, this study provides a sample of websites and providers, and thus may not be indicative of all suppliers selling over-the-counter antibiotics. Even with these strategies, however, it was difficult to know whether one corporation still owns and manages several locations. We compared identifying telephone numbers, street addresses, and site headers for each site as a way to sort out duplication. Our study suggests that the opposite might be the case. All these obstacles cause the illegal acquisition of antibiotics by patients. Thus, vendors targeting foreign-language speakers in the United States would have been missed. Reducing inappropriate use of antibiotics is key to many antibiotic resistance initiatives. This practice also occurs in the United States even though the United States regulates the acquisition of antibiotics, which will be limited by prescription only. Unfortunately, other disturbing evidence suggests that this problem may not be easily fixed through education, a troubling issue in controlling antibiotic use. Because of its effect on morbidity and mortality, antibiotic resistance is considered a threat to US health and national security by the Institute of Medicine and the Infectious Diseases Society of America. Previous research suggests that a patient's past experience of care seeking and treatment use influences future expectations for treatment of respiratory tract infections.