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Moreover, pharmaceutical companies may need to monitor who is selling their products and through what mechanisms. Fourth, we categorized whether a person could buy antibiotics, especially broad-spectrum antibiotics, in quantities greater than what would be considered adequate 1 course of treatment for acute respiratory tract infection. If those who are self-medicating are taught that they put their own health at risk, they may be less likely to use these online pharmacies. We assessed whether individuals could purchase penicillins, macrolides, fluoroquinolones, and cephalosporins, because the availability of multiple classes of antibiotics would affect additional selective pressure in the community. As some vendors have multiple URLs to reach their company, we checked the mailing address, title and phone number to avoid double counting. No prescription was required, and no online consultation was necessary. Self-administration of antibiotics occurs in all countries, but it is particularly problematic where the use of antimicrobials without a prescription is encouraged by the lack of laws restricting antibiotic sales or a failure to enforce the laws. As websites appear and disappear at a relative frequency, searches and classifications were performed during the first week of September 2008. We considered more than 6 pills to be excessive and could lead to future self-medication with the unused pills. We classified Web sites of vendors according to several variables. In addition, the ability of Internet-based companies to exist without an identifiable physical location or property makes the location and writing of FDA instructions extremely difficult. The frequency of relevant Web sites declined substantially after the first 300. Further education aimed at patients and the community, as well as increased regulation and application of existing guidelines, can help control this potentially vast reservoir of antibiotics. This activity suggests that some vendors are aware of the questionable legitimacy of their business. If patients who are now denied antibiotics through their physician can access over-the-counter medications, the overall level of antibiotic use in the general population can actually increase and thus have a significant effect on rates of resistance to microbial degradation.