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We compared identifying telephone numbers, street addresses, and site headers for each site as a way to sort out duplication. Self-administration of antibiotics occurs in all countries, but it is particularly problematic where the use of antimicrobials without a prescription is encouraged by the lack of laws restricting antibiotic sales or a failure to enforce the laws. Antibiotics serve a useful therapeutic purpose in treating and controlling the effects of infectious agents. To examine the types of Web sites and vendors dispensing antibiotics on the Internet, we conducted a search using 2 major search engines (Google and Yahoo) and the key words "purchase antibiotics without prescription" and "online (English only). Although more than half of the identified sites provided online consultation for prescribing, the lack of interaction between the patient and the doctor did not lead to any opportunity for patient education. Most initiatives, however, focus almost exclusively on controlling prescribing by health care clinicians and do not focus on patient self-medication. For this second group, no prescription from a doctor or clinical physician was necessary before gaining access to the site. Some prescription medication is sold without a valid prescription, which is a violation of the Federal Food, Drug, and Cosmetic Act. This phenomenon has not been the focus of initiatives to control antibiotic resistance. Because of its effect on morbidity and mortality, antibiotic resistance is considered a threat to US health and national security by the Institute of Medicine and the Infectious Diseases Society of America. The first 300 search results of on both sites were examined to identify vendors for antibiotics that did not require a prescription. Antibiotic resistance is a common problem, however, and has been described with numerous infectious agents and in varying contexts. We classified Web sites of vendors according to several variables. As a result, most community assessments of antibiotic reservoirs are based on assessments by prescribing clinician behavior. Second, there was a considerable repetition in the Web sites, which made an accurate determination of unique vendors from the 184 different sites difficult, an effort that may have let to some error. First, although all of the included providers would sell antibiotics without a prescription, we assessed whether the supplier would sell antibiotics without any form of prescription or whether a prescription created for the purchase based on the completion of an online medical history was required.