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Unfortunately, this strategy of focusing on prescribing practices does not address the behavior of self-medication with antibiotics. The links to these advertised sites were also investigated. Our study is the first to document this phenomenon, and we describe the mechanism for purchasing antibiotics online; future studies will need to document the scope of antibiotics purchased through this mechanism to better understand its direct implications for antibiotic resistance. Since the websites suggested a range of days for the expected treatment receipt, we used the median to represent the expected delivery time. If those who are self-medicating are taught that they put their own health at risk, they may be less likely to use these online pharmacies. In usual face-to-face health care visits for respiratory tract infections during which antibiotics are prescribed, more than 90% of prescriptions are filled on the day of the office visit. The first 300 search results of on both sites were examined to identify vendors for antibiotics that did not require a prescription. Second, we examined whether the vendor would ship prescription antibiotics to a buyer in the United States, as well as several other countries (Canada, United Kingdom) where antibiotics are available only by prescription. The frequency of relevant Web sites declined substantially after the first 300. Clinicians evaluating the patient's use of self-medication when taking a medical history may function as an important opportunity to tell patients about not only antibiotic resistance, but also potential interactions between antibiotics and other prescription drugs. There are several limitations to this study. In addition, the available quantities and the interval between prescribing and receiving treatment suggest that these transactions will likely be used by people storing drugs for future self-diagnosis and treatment, or for sale. For this second group, no prescription from a doctor or clinical physician was necessary before gaining access to the site. The purpose of this study was to examine antibiotics available to patients without a prescription, a phenomenon on the Internet. For example, we found that servers at Dartmouth College, East Carolina University, University of Pittsburgh, Carnegie Mellon University, and California State University in San Francisco were all used, most likely without their knowledge, to be reassigned to online pharmacies.