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We classified Web sites of vendors according to several variables. There are several limitations to this study. Finally, in order to determine whether these sites actually provide a product that they intended to sell over the counter, we submitted an online order to 1 vendor for 6 tablets of azithromycin, 500 mg each. In usual face-to-face health care visits for respiratory tract infections during which antibiotics are prescribed, more than 90% of prescriptions are filled on the day of the office visit. Although the vast majority of websites were in English, some were in other languages. Several studies suggest that antibiotic prescribing for viral illnesses, respiratory tract infections being one example, has declined in the last decade. Although excessive consumption of antibiotics has contributed to the spread of antibiotic resistance, 4-6 most initiatives regarding inappropriate direct human consumption of the antibiotic therapy center are almost exclusively controlled by prescribing by healthcare clinicians. The frequency of relevant Web sites declined substantially after the first 300. Increased regulation of sites outside of controlled substances to include antibiotics seems guaranteed and necessary. Thus, as soon as patients receive over-the-counter antibiotics and self-treating self-limiting illnesses with drugs, such as upper-respiratory tract infections without complications, they are likely to suggest that the antibiotic was effective, and self-medicate in the future. The links to these advertised sites were also investigated. As some vendors have multiple URLs to reach their company, we checked the mailing address, title and phone number to avoid double counting. If patients who are now denied antibiotics through their physician can access over-the-counter medications, the overall level of antibiotic use in the general population can actually increase and thus have a significant effect on rates of resistance to microbial degradation. As part of this study, we bought over-the-counter antibiotics over the counter. As a result, most community assessments of antibiotic reservoirs are based on assessments by prescribing clinician behavior. Thus, vendors targeting foreign-language speakers in the United States would have been missed.