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We assessed whether individuals could purchase penicillins, macrolides, fluoroquinolones, and cephalosporins, because the availability of multiple classes of antibiotics would affect additional selective pressure in the community. The US Food and Drug Administration forbids ordering prescription drugs from outside the United States: Thus, in virtually all instances, individual citizens are prohibited from importing prescription drugs into the United States. Although the vast majority of websites were in English, some were in other languages. We considered more than 6 pills to be excessive and could lead to future self-medication with the unused pills. Second, we examined whether the vendor would ship prescription antibiotics to a buyer in the United States, as well as several other countries (Canada, United Kingdom) where antibiotics are available only by prescription. In addition, the ability of Internet-based companies to exist without an identifiable physical location or property makes the location and writing of FDA instructions extremely difficult. No prescription was required, and no online consultation was necessary. Moreover, pharmaceutical companies may need to monitor who is selling their products and through what mechanisms. Several studies suggest that antibiotic prescribing for viral illnesses, respiratory tract infections being one example, has declined in the last decade. Even with these strategies, however, it was difficult to know whether one corporation still owns and manages several locations. That these companies can be located in countries outside US jurisdictions complicates enforcement of US laws. Our study is the first to document this phenomenon, and we describe the mechanism for purchasing antibiotics online; future studies will need to document the scope of antibiotics purchased through this mechanism to better understand its direct implications for antibiotic resistance. For this second group, no prescription from a doctor or clinical physician was necessary before gaining access to the site. As part of this study, we bought over-the-counter antibiotics over the counter. This activity suggests that some vendors are aware of the questionable legitimacy of their business. Fourth, we categorized whether a person could buy antibiotics, especially broad-spectrum antibiotics, in quantities greater than what would be considered adequate 1 course of treatment for acute respiratory tract infection.