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Clinicians evaluating the patient's use of self-medication when taking a medical history may function as an important opportunity to tell patients about not only antibiotic resistance, but also potential interactions between antibiotics and other prescription drugs. Further education aimed at patients and the community, as well as increased regulation and application of existing guidelines, can help control this potentially vast reservoir of antibiotics. Even with these strategies, however, it was difficult to know whether one corporation still owns and manages several locations. Thus, vendors targeting foreign-language speakers in the United States would have been missed. In addition, the available quantities and the interval between prescribing and receiving treatment suggest that these transactions will likely be used by people storing drugs for future self-diagnosis and treatment, or for sale. Fifth, we estimated the expected delivery time to take antibiotics. In conclusion, antibiotics are freely available for purchase over the Internet without a prescription, and the general structure of transactions encourages self-medication and poor quality care. After completing the online medical history, the customer would be given a prescription that would allow the purchase to be completed. The vendors identified in this study do not appear to be fearful of prosecution. This decrease was interpreted as evidence that the full use of antibiotics was also reduced. Patients are increasingly using the Internet not only to access health information but also to obtain medication. We assessed whether individuals could purchase penicillins, macrolides, fluoroquinolones, and cephalosporins, because the availability of multiple classes of antibiotics would affect additional selective pressure in the community. The purpose of this study was to examine antibiotics available to patients without a prescription, a phenomenon on the Internet. Finally, in order to determine whether these sites actually provide a product that they intended to sell over the counter, we submitted an online order to 1 vendor for 6 tablets of azithromycin, 500 mg each. Some Internet vendors also attempt to skirt US regulations by operating in countries outside the United States but marketing to US consumers.