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Antibiotic resistance is a common problem, however, and has been described with numerous infectious agents and in varying contexts. We therefore wanted to find out if the amount of time between online evaluation and getting treatment was significantly longer. This activity suggests that some vendors are aware of the questionable legitimacy of their business. The medical community and the public health and regulating agencies, as well as pharmaceutical companies, need to expand efforts to control antibiotic resistance beyond initiatives centered on prescribing behavior to include self-medication and sources of antibiotics obtained without prescription. We compared identifying telephone numbers, street addresses, and site headers for each site as a way to sort out duplication. The first 300 search results of on both sites were examined to identify vendors for antibiotics that did not require a prescription. First, although all of the included providers would sell antibiotics without a prescription, we assessed whether the supplier would sell antibiotics without any form of prescription or whether a prescription created for the purchase based on the completion of an online medical history was required. This phenomenon has not been the focus of initiatives to control antibiotic resistance. Our purchase arrived from Mexico with no information on instructions for use of the medication. This study was not meant to be an exhaustive census of these sites, primarily because with the questionable legality of some of these practices, these sites rapidly come and go. As part of this study, we bought over-the-counter antibiotics over the counter. Patients are increasingly using the Internet not only to access health information but also to obtain medication. Self-administration of antibiotics occurs in all countries, but it is particularly problematic where the use of antimicrobials without a prescription is encouraged by the lack of laws restricting antibiotic sales or a failure to enforce the laws. Our study is the first to document this phenomenon, and we describe the mechanism for purchasing antibiotics online; future studies will need to document the scope of antibiotics purchased through this mechanism to better understand its direct implications for antibiotic resistance. The links to these advertised sites were also investigated.