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Patients are increasingly using the Internet not only to access health information but also to obtain medication. We compared identifying telephone numbers, street addresses, and site headers for each site as a way to sort out duplication. We considered more than 6 pills to be excessive and could lead to future self-medication with the unused pills. Fifth, we estimated the expected delivery time to take antibiotics. Further education aimed at patients and the community, as well as increased regulation and application of existing guidelines, can help control this potentially vast reservoir of antibiotics. The medical community and the public health and regulating agencies, as well as pharmaceutical companies, need to expand efforts to control antibiotic resistance beyond initiatives centered on prescribing behavior to include self-medication and sources of antibiotics obtained without prescription. As part of this study, we bought over-the-counter antibiotics over the counter. Other providers are trying to upset this law by providing online diagnoses and prescriptions based on medical records without a physical examination and without a long relationship between the patient and the doctor, a practice that is not considered an adequate standard of care. Moreover, pharmaceutical companies may need to monitor who is selling their products and through what mechanisms. In some cases the URL did not take the reader to an actual medication vendor; rather, the Web site contained multiple advertisements and links to other sites for purchasing antibiotics. European countries struggled with the problem of self-medication with antibiotics and found that the belief in the appropriateness of self-medication with antibiotics for bronchitis and the perceived availability of antibiotics without a prescription was associated with an increased likelihood of self-medication. The purpose of this study was to examine antibiotics available to patients without a prescription, a phenomenon on the Internet. Our purchase arrived from Mexico with no information on instructions for use of the medication. Most initiatives, however, focus almost exclusively on controlling prescribing by health care clinicians and do not focus on patient self-medication. Second, there was a considerable repetition in the Web sites, which made an accurate determination of unique vendors from the 184 different sites difficult, an effort that may have let to some error.