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We considered more than 6 pills to be excessive and could lead to future self-medication with the unused pills. There are several limitations to this study. We classified Web sites of vendors according to several variables. First, this study provides a sample of websites and providers, and thus may not be indicative of all suppliers selling over-the-counter antibiotics. Although providing over-the-counter drugs is illegal in the United States, failure to enforce US laws likely encourages these companies to sell their products to patients. Fifth, we estimated the expected delivery time to take antibiotics. Our purchase arrived from Mexico with no information on instructions for use of the medication. The medical community and the public health and regulating agencies, as well as pharmaceutical companies, need to expand efforts to control antibiotic resistance beyond initiatives centered on prescribing behavior to include self-medication and sources of antibiotics obtained without prescription. This study was not meant to be an exhaustive census of these sites, primarily because with the questionable legality of some of these practices, these sites rapidly come and go. No prescription was required, and no online consultation was necessary. Unfortunately, this strategy of focusing on prescribing practices does not address the behavior of self-medication with antibiotics. In conclusion, antibiotics are freely available for purchase over the Internet without a prescription, and the general structure of transactions encourages self-medication and poor quality care. Most initiatives, however, focus almost exclusively on controlling prescribing by health care clinicians and do not focus on patient self-medication. Since the websites suggested a range of days for the expected treatment receipt, we used the median to represent the expected delivery time. This practice also occurs in the United States even though the United States regulates the acquisition of antibiotics, which will be limited by prescription only. We compared identifying telephone numbers, street addresses, and site headers for each site as a way to sort out duplication.