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As some vendors have multiple URLs to reach their company, we checked the mailing address, title and phone number to avoid double counting. Although more than half of the identified sites provided online consultation for prescribing, the lack of interaction between the patient and the doctor did not lead to any opportunity for patient education. Our final list of URLs included 184 links to single vendors of antibiotics. We therefore wanted to find out if the amount of time between online evaluation and getting treatment was significantly longer. Antibiotics serve a useful therapeutic purpose in treating and controlling the effects of infectious agents. That these companies can be located in countries outside US jurisdictions complicates enforcement of US laws. We considered more than 6 pills to be excessive and could lead to future self-medication with the unused pills. This decrease was interpreted as evidence that the full use of antibiotics was also reduced. This practice also occurs in the United States even though the United States regulates the acquisition of antibiotics, which will be limited by prescription only. In usual face-to-face health care visits for respiratory tract infections during which antibiotics are prescribed, more than 90% of prescriptions are filled on the day of the office visit. Although excessive consumption of antibiotics has contributed to the spread of antibiotic resistance, 4-6 most initiatives regarding inappropriate direct human consumption of the antibiotic therapy center are almost exclusively controlled by prescribing by healthcare clinicians. Third, we categorized the classes of antibiotics available for purchase. In the case of online histories to justify a prescription, we assumed that individuals are primarily purchasing antibiotics for an acute problem. Self-administration of antibiotics occurs in all countries, but it is particularly problematic where the use of antimicrobials without a prescription is encouraged by the lack of laws restricting antibiotic sales or a failure to enforce the laws. Finally, and potentially the biggest limitation on the importance of this study, is that we were unable to describe how this Internet-based purchasing strategy was used to purchase people with antibiotics in the United States. We compared identifying telephone numbers, street addresses, and site headers for each site as a way to sort out duplication.