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Because of its effect on morbidity and mortality, antibiotic resistance is considered a threat to US health and national security by the Institute of Medicine and the Infectious Diseases Society of America. Finally, and potentially the biggest limitation on the importance of this study, is that we were unable to describe how this Internet-based purchasing strategy was used to purchase people with antibiotics in the United States. There are several limitations to this study. Third, we categorized the classes of antibiotics available for purchase. This phenomenon has not been the focus of initiatives to control antibiotic resistance. First, this study provides a sample of websites and providers, and thus may not be indicative of all suppliers selling over-the-counter antibiotics. If patients who are now denied antibiotics through their physician can access over-the-counter medications, the overall level of antibiotic use in the general population can actually increase and thus have a significant effect on rates of resistance to microbial degradation. As a result, most community assessments of antibiotic reservoirs are based on assessments by prescribing clinician behavior. This activity suggests that some vendors are aware of the questionable legitimacy of their business. Increased regulation of sites outside of controlled substances to include antibiotics seems guaranteed and necessary. We assessed whether individuals could purchase penicillins, macrolides, fluoroquinolones, and cephalosporins, because the availability of multiple classes of antibiotics would affect additional selective pressure in the community. All these obstacles cause the illegal acquisition of antibiotics by patients. Thus, as soon as patients receive over-the-counter antibiotics and self-treating self-limiting illnesses with drugs, such as upper-respiratory tract infections without complications, they are likely to suggest that the antibiotic was effective, and self-medicate in the future. The links to these advertised sites were also investigated. In the case of online histories to justify a prescription, we assumed that individuals are primarily purchasing antibiotics for an acute problem. Fifth, we estimated the expected delivery time to take antibiotics.