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Specifically, we classified a single course of azithromycin as 6 pills, 250 mg each. Further education aimed at patients and the community, as well as increased regulation and application of existing guidelines, can help control this potentially vast reservoir of antibiotics. We classified Web sites of vendors according to several variables. The findings described in this study suggest that there is a potentially large pool of antibiotics in the United States that is not affected by initiatives to change physician-prescribing practices and may be contributing to antibiotic resistance. As part of this study, we bought over-the-counter antibiotics over the counter. We compared identifying telephone numbers, street addresses, and site headers for each site as a way to sort out duplication. Antibiotic resistance is a common problem, however, and has been described with numerous infectious agents and in varying contexts. Unfortunately, other disturbing evidence suggests that this problem may not be easily fixed through education, a troubling issue in controlling antibiotic use. In usual face-to-face health care visits for respiratory tract infections during which antibiotics are prescribed, more than 90% of prescriptions are filled on the day of the office visit. Increased regulation of sites outside of controlled substances to include antibiotics seems guaranteed and necessary. After completing the online medical history, the customer would be given a prescription that would allow the purchase to be completed. We considered more than 6 pills to be excessive and could lead to future self-medication with the unused pills. The first 300 search results of on both sites were examined to identify vendors for antibiotics that did not require a prescription. This reservoir of antibiotics is likely to be used inappropriately-the Web sites promote self-diagnosis and self-medication, and antibiotics are likely to be used in inappropriate dosages. First, although all of the included providers would sell antibiotics without a prescription, we assessed whether the supplier would sell antibiotics without any form of prescription or whether a prescription created for the purchase based on the completion of an online medical history was required. The extended delay between diagnosis and treatment receipt has consequences for resolving self-limiting conditions and storing unused treatment.