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The medical community and the public health and regulating agencies, as well as pharmaceutical companies, need to expand efforts to control antibiotic resistance beyond initiatives centered on prescribing behavior to include self-medication and sources of antibiotics obtained without prescription. In our analysis of evidence of the concept of buying 6 tablets of azithromycin, 500 mg each. Although excessive consumption of antibiotics has contributed to the spread of antibiotic resistance, 4-6 most initiatives regarding inappropriate direct human consumption of the antibiotic therapy center are almost exclusively controlled by prescribing by healthcare clinicians. Unfortunately, this strategy of focusing on prescribing practices does not address the behavior of self-medication with antibiotics. The frequency of relevant Web sites declined substantially after the first 300. Some prescription medication is sold without a valid prescription, which is a violation of the Federal Food, Drug, and Cosmetic Act. For this second group, no prescription from a doctor or clinical physician was necessary before gaining access to the site. Specifically, we classified a single course of azithromycin as 6 pills, 250 mg each. Although more than half of the identified sites provided online consultation for prescribing, the lack of interaction between the patient and the doctor did not lead to any opportunity for patient education. Moreover, pharmaceutical companies may need to monitor who is selling their products and through what mechanisms. Some Internet vendors also attempt to skirt US regulations by operating in countries outside the United States but marketing to US consumers. Third, we categorized the classes of antibiotics available for purchase. The extent to which antibiotics are available for over-the-counter purchases over the Internet is unknown. This phenomenon has not been the focus of initiatives to control antibiotic resistance. Previous research suggests that a patient's past experience of care seeking and treatment use influences future expectations for treatment of respiratory tract infections.