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In usual face-to-face health care visits for respiratory tract infections during which antibiotics are prescribed, more than 90% of prescriptions are filled on the day of the office visit. Thus, as soon as patients receive over-the-counter antibiotics and self-treating self-limiting illnesses with drugs, such as upper-respiratory tract infections without complications, they are likely to suggest that the antibiotic was effective, and self-medicate in the future. As a result, most community assessments of antibiotic reservoirs are based on assessments by prescribing clinician behavior. Fourth, we categorized whether a person could buy antibiotics, especially broad-spectrum antibiotics, in quantities greater than what would be considered adequate 1 course of treatment for acute respiratory tract infection. All these obstacles cause the illegal acquisition of antibiotics by patients. As websites appear and disappear at a relative frequency, searches and classifications were performed during the first week of September 2008. The links to these advertised sites were also investigated. This study was not meant to be an exhaustive census of these sites, primarily because with the questionable legality of some of these practices, these sites rapidly come and go. Reducing inappropriate use of antibiotics is key to many antibiotic resistance initiatives. Second, we examined whether the vendor would ship prescription antibiotics to a buyer in the United States, as well as several other countries (Canada, United Kingdom) where antibiotics are available only by prescription. Even with these strategies, however, it was difficult to know whether one corporation still owns and manages several locations. The vendors identified in this study do not appear to be fearful of prosecution. Second, there was a considerable repetition in the Web sites, which made an accurate determination of unique vendors from the 184 different sites difficult, an effort that may have let to some error. There are several limitations to this study. Unfortunately, this strategy of focusing on prescribing practices does not address the behavior of self-medication with antibiotics. Moreover, pharmaceutical companies may need to monitor who is selling their products and through what mechanisms.