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We assessed whether individuals could purchase penicillins, macrolides, fluoroquinolones, and cephalosporins, because the availability of multiple classes of antibiotics would affect additional selective pressure in the community. Fourth, we have limited our count to English language websites. European countries struggled with the problem of self-medication with antibiotics and found that the belief in the appropriateness of self-medication with antibiotics for bronchitis and the perceived availability of antibiotics without a prescription was associated with an increased likelihood of self-medication. Other providers are trying to upset this law by providing online diagnoses and prescriptions based on medical records without a physical examination and without a long relationship between the patient and the doctor, a practice that is not considered an adequate standard of care. All these obstacles cause the illegal acquisition of antibiotics by patients. Reducing inappropriate use of antibiotics is key to many antibiotic resistance initiatives. First, this study provides a sample of websites and providers, and thus may not be indicative of all suppliers selling over-the-counter antibiotics. Because of its effect on morbidity and mortality, antibiotic resistance is considered a threat to US health and national security by the Institute of Medicine and the Infectious Diseases Society of America. Even with these strategies, however, it was difficult to know whether one corporation still owns and manages several locations. We classified Web sites of vendors according to several variables. In addition, the available quantities and the interval between prescribing and receiving treatment suggest that these transactions will likely be used by people storing drugs for future self-diagnosis and treatment, or for sale. If those who are self-medicating are taught that they put their own health at risk, they may be less likely to use these online pharmacies. Several studies suggest that antibiotic prescribing for viral illnesses, respiratory tract infections being one example, has declined in the last decade. Unfortunately, this strategy of focusing on prescribing practices does not address the behavior of self-medication with antibiotics. Increased regulation of sites outside of controlled substances to include antibiotics seems guaranteed and necessary.