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First, this study provides a sample of websites and providers, and thus may not be indicative of all suppliers selling over-the-counter antibiotics. Self-administration of antibiotics occurs in all countries, but it is particularly problematic where the use of antimicrobials without a prescription is encouraged by the lack of laws restricting antibiotic sales or a failure to enforce the laws. We therefore wanted to find out if the amount of time between online evaluation and getting treatment was significantly longer. Antibiotic resistance is a common problem, however, and has been described with numerous infectious agents and in varying contexts. This decrease was interpreted as evidence that the full use of antibiotics was also reduced. In the case of online histories to justify a prescription, we assumed that individuals are primarily purchasing antibiotics for an acute problem. Although providing over-the-counter drugs is illegal in the United States, failure to enforce US laws likely encourages these companies to sell their products to patients. As some vendors have multiple URLs to reach their company, we checked the mailing address, title and phone number to avoid double counting. The frequency of relevant Web sites declined substantially after the first 300. Antibiotics serve a useful therapeutic purpose in treating and controlling the effects of infectious agents. The extent to which antibiotics are available for over-the-counter purchases over the Internet is unknown. There are several limitations to this study. Patients are increasingly using the Internet not only to access health information but also to obtain medication. Thus, vendors targeting foreign-language speakers in the United States would have been missed. Recent evidence in ethnic communities in the United States indicates a high level of self-medication with antibiotics either obtained without a prescription in a foreign country and imported into the United States or acquired in the United States without a prescription at stores in ethnic communities. Finally, in order to determine whether these sites actually provide a product that they intended to sell over the counter, we submitted an online order to 1 vendor for 6 tablets of azithromycin, 500 mg each.