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Although excessive consumption of antibiotics has contributed to the spread of antibiotic resistance, 4-6 most initiatives regarding inappropriate direct human consumption of the antibiotic therapy center are almost exclusively controlled by prescribing by healthcare clinicians. This practice also occurs in the United States even though the United States regulates the acquisition of antibiotics, which will be limited by prescription only. Although more than half of the identified sites provided online consultation for prescribing, the lack of interaction between the patient and the doctor did not lead to any opportunity for patient education. Previous research suggests that a patient's past experience of care seeking and treatment use influences future expectations for treatment of respiratory tract infections. In addition, the available quantities and the interval between prescribing and receiving treatment suggest that these transactions will likely be used by people storing drugs for future self-diagnosis and treatment, or for sale. The frequency of relevant Web sites declined substantially after the first 300. Antibiotics serve a useful therapeutic purpose in treating and controlling the effects of infectious agents. Thus, vendors targeting foreign-language speakers in the United States would have been missed. Antibiotic resistance is a common problem, however, and has been described with numerous infectious agents and in varying contexts. The extent to which antibiotics are available for over-the-counter purchases over the Internet is unknown. Reducing inappropriate use of antibiotics is key to many antibiotic resistance initiatives. We therefore wanted to find out if the amount of time between online evaluation and getting treatment was significantly longer. The medical community and the public health and regulating agencies, as well as pharmaceutical companies, need to expand efforts to control antibiotic resistance beyond initiatives centered on prescribing behavior to include self-medication and sources of antibiotics obtained without prescription. European countries struggled with the problem of self-medication with antibiotics and found that the belief in the appropriateness of self-medication with antibiotics for bronchitis and the perceived availability of antibiotics without a prescription was associated with an increased likelihood of self-medication. Second, there was a considerable repetition in the Web sites, which made an accurate determination of unique vendors from the 184 different sites difficult, an effort that may have let to some error. This reservoir of antibiotics is likely to be used inappropriately-the Web sites promote self-diagnosis and self-medication, and antibiotics are likely to be used in inappropriate dosages.