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Fourth, we categorized whether a person could buy antibiotics, especially broad-spectrum antibiotics, in quantities greater than what would be considered adequate 1 course of treatment for acute respiratory tract infection. We therefore wanted to find out if the amount of time between online evaluation and getting treatment was significantly longer. In usual face-to-face health care visits for respiratory tract infections during which antibiotics are prescribed, more than 90% of prescriptions are filled on the day of the office visit. Although more than half of the identified sites provided online consultation for prescribing, the lack of interaction between the patient and the doctor did not lead to any opportunity for patient education. Finally, in order to determine whether these sites actually provide a product that they intended to sell over the counter, we submitted an online order to 1 vendor for 6 tablets of azithromycin, 500 mg each. This phenomenon has not been the focus of initiatives to control antibiotic resistance. If those who are self-medicating are taught that they put their own health at risk, they may be less likely to use these online pharmacies. Unfortunately, other disturbing evidence suggests that this problem may not be easily fixed through education, a troubling issue in controlling antibiotic use. Patients are increasingly using the Internet not only to access health information but also to obtain medication. This activity suggests that some vendors are aware of the questionable legitimacy of their business. Our study is the first to document this phenomenon, and we describe the mechanism for purchasing antibiotics online; future studies will need to document the scope of antibiotics purchased through this mechanism to better understand its direct implications for antibiotic resistance. The vendors identified in this study do not appear to be fearful of prosecution. Unfortunately, this strategy of focusing on prescribing practices does not address the behavior of self-medication with antibiotics. The purpose of this study was to examine antibiotics available to patients without a prescription, a phenomenon on the Internet. Some prescription medication is sold without a valid prescription, which is a violation of the Federal Food, Drug, and Cosmetic Act. In conclusion, antibiotics are freely available for purchase over the Internet without a prescription, and the general structure of transactions encourages self-medication and poor quality care.