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Because of its effect on morbidity and mortality, antibiotic resistance is considered a threat to US health and national security by the Institute of Medicine and the Infectious Diseases Society of America. Third, we could not to determine how often pharmaceuticals purchased over the Internet were not genuine, inactive, out of date, or adulterated. Although more than half of the identified sites provided online consultation for prescribing, the lack of interaction between the patient and the doctor did not lead to any opportunity for patient education. Even with these strategies, however, it was difficult to know whether one corporation still owns and manages several locations. The extended delay between diagnosis and treatment receipt has consequences for resolving self-limiting conditions and storing unused treatment. The vendors identified in this study do not appear to be fearful of prosecution. Although the vast majority of websites were in English, some were in other languages. Unfortunately, this strategy of focusing on prescribing practices does not address the behavior of self-medication with antibiotics. Several studies suggest that antibiotic prescribing for viral illnesses, respiratory tract infections being one example, has declined in the last decade. This activity suggests that some vendors are aware of the questionable legitimacy of their business. As a result, most community assessments of antibiotic reservoirs are based on assessments by prescribing clinician behavior. This decrease was interpreted as evidence that the full use of antibiotics was also reduced. Antibiotics serve a useful therapeutic purpose in treating and controlling the effects of infectious agents. Some Internet vendors also attempt to skirt US regulations by operating in countries outside the United States but marketing to US consumers. The links to these advertised sites were also investigated.