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In addition, the available quantities and the interval between prescribing and receiving treatment suggest that these transactions will likely be used by people storing drugs for future self-diagnosis and treatment, or for sale. Even with these strategies, however, it was difficult to know whether one corporation still owns and manages several locations. We therefore wanted to find out if the amount of time between online evaluation and getting treatment was significantly longer. Patients are increasingly using the Internet not only to access health information but also to obtain medication. There are several limitations to this study. In some cases the URL did not take the reader to an actual medication vendor; rather, the Web site contained multiple advertisements and links to other sites for purchasing antibiotics. Clinicians evaluating the patient's use of self-medication when taking a medical history may function as an important opportunity to tell patients about not only antibiotic resistance, but also potential interactions between antibiotics and other prescription drugs. Our purchase arrived from Mexico with no information on instructions for use of the medication. Several studies suggest that antibiotic prescribing for viral illnesses, respiratory tract infections being one example, has declined in the last decade. Further education aimed at patients and the community, as well as increased regulation and application of existing guidelines, can help control this potentially vast reservoir of antibiotics. As part of this study, we bought over-the-counter antibiotics over the counter. Finally, and potentially the biggest limitation on the importance of this study, is that we were unable to describe how this Internet-based purchasing strategy was used to purchase people with antibiotics in the United States. Some Internet vendors also attempt to skirt US regulations by operating in countries outside the United States but marketing to US consumers. As websites appear and disappear at a relative frequency, searches and classifications were performed during the first week of September 2008. The frequency of relevant Web sites declined substantially after the first 300.