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We assessed whether individuals could purchase penicillins, macrolides, fluoroquinolones, and cephalosporins, because the availability of multiple classes of antibiotics would affect additional selective pressure in the community. As a result, most community assessments of antibiotic reservoirs are based on assessments by prescribing clinician behavior. In conclusion, antibiotics are freely available for purchase over the Internet without a prescription, and the general structure of transactions encourages self-medication and poor quality care. This practice also occurs in the United States even though the United States regulates the acquisition of antibiotics, which will be limited by prescription only. This decrease was interpreted as evidence that the full use of antibiotics was also reduced. Unfortunately, other disturbing evidence suggests that this problem may not be easily fixed through education, a troubling issue in controlling antibiotic use. As websites appear and disappear at a relative frequency, searches and classifications were performed during the first week of September 2008. Unfortunately, this strategy of focusing on prescribing practices does not address the behavior of self-medication with antibiotics. All these obstacles cause the illegal acquisition of antibiotics by patients. Our study suggests that the opposite might be the case. Further education aimed at patients and the community, as well as increased regulation and application of existing guidelines, can help control this potentially vast reservoir of antibiotics. This study was not meant to be an exhaustive census of these sites, primarily because with the questionable legality of some of these practices, these sites rapidly come and go. As some vendors have multiple URLs to reach their company, we checked the mailing address, title and phone number to avoid double counting. That these companies can be located in countries outside US jurisdictions complicates enforcement of US laws. Moreover, pharmaceutical companies may need to monitor who is selling their products and through what mechanisms. The links to these advertised sites were also investigated.