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After completing the online medical history, the customer would be given a prescription that would allow the purchase to be completed. Unfortunately, this strategy of focusing on prescribing practices does not address the behavior of self-medication with antibiotics. Although more than half of the identified sites provided online consultation for prescribing, the lack of interaction between the patient and the doctor did not lead to any opportunity for patient education. In the case of online histories to justify a prescription, we assumed that individuals are primarily purchasing antibiotics for an acute problem. Reducing inappropriate use of antibiotics is key to many antibiotic resistance initiatives. Our study suggests that the opposite might be the case. Fourth, we have limited our count to English language websites. First, although all of the included providers would sell antibiotics without a prescription, we assessed whether the supplier would sell antibiotics without any form of prescription or whether a prescription created for the purchase based on the completion of an online medical history was required. Some Internet vendors also attempt to skirt US regulations by operating in countries outside the United States but marketing to US consumers. We compared identifying telephone numbers, street addresses, and site headers for each site as a way to sort out duplication. European countries struggled with the problem of self-medication with antibiotics and found that the belief in the appropriateness of self-medication with antibiotics for bronchitis and the perceived availability of antibiotics without a prescription was associated with an increased likelihood of self-medication. Clinicians evaluating the patient's use of self-medication when taking a medical history may function as an important opportunity to tell patients about not only antibiotic resistance, but also potential interactions between antibiotics and other prescription drugs. Although providing over-the-counter drugs is illegal in the United States, failure to enforce US laws likely encourages these companies to sell their products to patients. Moreover, pharmaceutical companies may need to monitor who is selling their products and through what mechanisms. The medical community and the public health and regulating agencies, as well as pharmaceutical companies, need to expand efforts to control antibiotic resistance beyond initiatives centered on prescribing behavior to include self-medication and sources of antibiotics obtained without prescription. As some vendors have multiple URLs to reach their company, we checked the mailing address, title and phone number to avoid double counting.