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If those who are self-medicating are taught that they put their own health at risk, they may be less likely to use these online pharmacies. In addition, the ability of Internet-based companies to exist without an identifiable physical location or property makes the location and writing of FDA instructions extremely difficult. There are several limitations to this study. In our analysis of evidence of the concept of buying 6 tablets of azithromycin, 500 mg each. Antibiotic resistance is a common problem, however, and has been described with numerous infectious agents and in varying contexts. After completing the online medical history, the customer would be given a prescription that would allow the purchase to be completed. In the case of online histories to justify a prescription, we assumed that individuals are primarily purchasing antibiotics for an acute problem. First, although all of the included providers would sell antibiotics without a prescription, we assessed whether the supplier would sell antibiotics without any form of prescription or whether a prescription created for the purchase based on the completion of an online medical history was required. Fourth, we have limited our count to English language websites. The first 300 search results of on both sites were examined to identify vendors for antibiotics that did not require a prescription. Thus, vendors targeting foreign-language speakers in the United States would have been missed. The frequency of relevant Web sites declined substantially after the first 300. Some Internet vendors also attempt to skirt US regulations by operating in countries outside the United States but marketing to US consumers. This reservoir of antibiotics is likely to be used inappropriately-the Web sites promote self-diagnosis and self-medication, and antibiotics are likely to be used in inappropriate dosages. Clinicians evaluating the patient's use of self-medication when taking a medical history may function as an important opportunity to tell patients about not only antibiotic resistance, but also potential interactions between antibiotics and other prescription drugs. The links to these advertised sites were also investigated.