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All these obstacles cause the illegal acquisition of antibiotics by patients. Moreover, pharmaceutical companies may need to monitor who is selling their products and through what mechanisms. This phenomenon has not been the focus of initiatives to control antibiotic resistance. As a result, most community assessments of antibiotic reservoirs are based on assessments by prescribing clinician behavior. To examine the types of Web sites and vendors dispensing antibiotics on the Internet, we conducted a search using 2 major search engines (Google and Yahoo) and the key words "purchase antibiotics without prescription" and "online (English only). This decrease was interpreted as evidence that the full use of antibiotics was also reduced. Patients are increasingly using the Internet not only to access health information but also to obtain medication. Other providers are trying to upset this law by providing online diagnoses and prescriptions based on medical records without a physical examination and without a long relationship between the patient and the doctor, a practice that is not considered an adequate standard of care. Because of its effect on morbidity and mortality, antibiotic resistance is considered a threat to US health and national security by the Institute of Medicine and the Infectious Diseases Society of America. Some prescription medication is sold without a valid prescription, which is a violation of the Federal Food, Drug, and Cosmetic Act. No prescription was required, and no online consultation was necessary. Most initiatives, however, focus almost exclusively on controlling prescribing by health care clinicians and do not focus on patient self-medication. Our study is the first to document this phenomenon, and we describe the mechanism for purchasing antibiotics online; future studies will need to document the scope of antibiotics purchased through this mechanism to better understand its direct implications for antibiotic resistance. Specifically, we classified a single course of azithromycin as 6 pills, 250 mg each. Thus, as soon as patients receive over-the-counter antibiotics and self-treating self-limiting illnesses with drugs, such as upper-respiratory tract infections without complications, they are likely to suggest that the antibiotic was effective, and self-medicate in the future. Increased regulation of sites outside of controlled substances to include antibiotics seems guaranteed and necessary.